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KMID : 0363420230370010001
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Journal of Korean Oriental Pediatrics
2023 Volume.37 No. 1 p.1 ~ p.14
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Effects of Samryungbaekchul-san on Childhood Anorexia: A Systematic Review and Meta-Analysis
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Lee He-Sol
Lee Sun-Haeng
Chang Gyu-Tae
Lee Bo-Ram
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Abstract
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Objectives This study aimed to evaluate the effect of Samryungbaekchul-san on childhood anorexia.
Methods We searched 11 English, Korean, Chinese, and Japanese databases for studies published up to May 30, 2022.
Randomized controlled trials (RCTs) assessing the effect of Samryungbaekchul-san on childhood anorexia were included. In the meta-analysis, relative risk (RR) and 95% confidence intervals (CI) were indicated as dichotomous variables, and mean difference (MD) or standardized mean difference (SMD) and 95% CIs were indicated as continuous variables.
Results We included 12 RCTs with 1345 participants. The Samryungbaekchul-san treatment group had a significantly higher total effective rate (TER) than that of the western medicine control group (RR 1.42, 95% CI 1.23?1.64, I 2 = 0%). The combined Samryungbaekchul-san and western medicine treatment group had significantly higher TER (RR 1.31, 95% CI 1.23 to 1.40, I2 = 0%) and levels of neuropeptide Y (SMD 0.93, 95% CI 0.47?1.39, I 2 = 70%) and ghrelin (SMD 1.45, 95% CI 1.14?1.76, I2 = 0%) than those of the western medicine alone group.
Additionally, leptin levels were significantly lower in the combined treatment group (SMD -1.19, 95% CI -1.88 to -0.51, I2 = 86%) compared with the western medicine alone group, although statistical heterogeneity was substantial.
Conclusions Samryungbaekchul-san may be effective for childhood anorexia. However, owing to limitations such as high clinical heterogeneity between the studies, unclear risks of biases, and insufficient reports of adverse events and follow-ups, well-designed RCTs with a low risk of bias are needed in the future.
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KEYWORD
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Anorexia, Samryungbaekchul-san, Children, Systematic review, Meta-analysis
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